The Alan E. Beer Center for Reproductive Immunology & Genetics helps families grow by researching and treating couples who experience recurrent miscarriages, multiple pregnancy losses or repeated in vitro fertilization failures.

Consequences of Recurrent Pregnancy Loss

 

 


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Category 5 Immunological Problems

Chapter 3: CD 19+5+ B Cells (2)

Problem
  1. Normal numbers are 2 - 10%.. Women with problems have increases in cell numbers above 10%.
  2. Produce antibodies to neurotransmitters, including serotonin, endorphins and enkaphlans.
  3. These antibodies cause the ovaries to be resistant to stimulation, cause a poor lining to develop, interfere with the muscle development of the uterus, and prevent blood flow to the lining of the uterus and muscle at the time of implantation.
  4. These antibodies can cause depression, fibromyalgia, sleep disorders, increasing PMS symptoms and night sweats.

Antibodies to Neurotransmitters

Zones 1, 2 & 3 of endometrium on day of ovulation
Muscle cells
Serotonin
Blood flow to Zone 3 Endorphins & enkaphlins are involved in the modeling of the 3 layers of endometrium

Antibodies to these lead to a thin "teflon" endometrium without a blood supply

Serotonin needed to change muscle cells of uterus to accommodate a pregnancy

Antibodies to serotonin leads to a uterus that does not accommodate a pregnancy

Consequences

  1. Follicles stimulate poorly and require heavy doses of fertility drugs to awaken.
  2. Endometrial lining is thin; it rarely gets above 7 mm.
  3. Three zones of the endometrial lining do not develop.
  4. Blood vessels do not enter zone three.
  5. Uterine smooth muscle remains quiet and does not contract three times in two minutes.
  6. Eggs are of poor quality, fertilize in vitro with difficulty, divide slowly or incompletely, are low grade embryos and embryos fragment.
  7. Women are depressed, sleep poorly, panic easily and experience symptoms of achiness and fibromyalgia.
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Alan E. Beer Center for Reproductive Immunology & Genetics
15151 National Ave. #2; Los Gatos, CA 95032; Phone: (408) 356-9500; Fax: (408) 356-9509; E-mail: info@repro-med.net.
Date: 7-6-08, Time: 2:20 pm.

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