Th17 Assay

The Alan E. Beer Medical Center for Reproductive Immunology is pleased to announce the availability of Th17 testing, a new marker of recurrent miscarriage. Blood T-cells that express the Th17 marker form a balance with T-regulatory (Treg) cells in normal pregnancy. When this balance is disturbed, either by high Th17 cells or low Treg cells, miscarriage can occur. When balance is restored by immune therapy, the pregnancy can succeed. Th17 testing is offered by ReproSource Laboratories of Woburn, MA. The testing is another cutting-edge advance that will help to guide treatment in women with recurrent pregnancy loss or failure.

References:

1. Fu B, Tian Z, Wei H. TH17 cells in human recurrent pregnancy loss and pre-eclampsia. Cell Mol Immunol. 2014;11(6):564-570.

2. Figueiredo AS, Schumacher A. The T helper type 17/regulatory T cell paradigm in pregnancy. Immunology. 2016;148(1):13-21.

3. Sereshki N, Gharagozloo M, Ostadi V, et al. Variations in T-helper 17 and Regulatory T Cells during The Menstrual Cycle in Peripheral Blood of Women with Recurrent Spontaneous Abortion. Int J Fertil Steril. 2014;8(1):59-66.